![Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnrm3819/MediaObjects/41580_2014_Article_BFnrm3819_Fig3_HTML.jpg)
Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology
![PDF] Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis. | Semantic Scholar PDF] Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/1fab03d33f093b807e4c4dea23eab368e3b4ae0c/3-Figure1-1.png)
PDF] Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis. | Semantic Scholar
![Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnrm3819/MediaObjects/41580_2014_Article_BFnrm3819_Fig1_HTML.jpg)
Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology
![The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy [Abstract] The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy [Abstract]](https://www.thno.org/v11/p9571/toc.jpg)
The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy [Abstract]
![Regulation of mitotic progression by Polo-like kinase 1 (PLK1). PLK1... | Download Scientific Diagram Regulation of mitotic progression by Polo-like kinase 1 (PLK1). PLK1... | Download Scientific Diagram](https://www.researchgate.net/publication/41485638/figure/fig2/AS:394199041101828@1470995783535/Fig-2-Regulation-of-mitotic-progression-by-Polo-like-kinase-1-PLK1-PLK1-critical.png)
Regulation of mitotic progression by Polo-like kinase 1 (PLK1). PLK1... | Download Scientific Diagram
![Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization | PNAS Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization | PNAS](https://www.pnas.org/cms/10.1073/pnas.0609131104/asset/57102753-3cda-4246-8459-be1f376e01e6/assets/graphic/zpq0030748700005.jpeg)
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization | PNAS
![Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis](https://pub.mdpi-res.com/cancers/cancers-09-00131/article_deploy/html/images/cancers-09-00131-g001.png?1569570923)
Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis
![Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential | Journal of Medicinal Chemistry Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.2c00614/asset/images/large/jm2c00614_0018.jpeg)
Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential | Journal of Medicinal Chemistry
![Figure 2 from Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. | Semantic Scholar Figure 2 from Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/22a093811fa1404a83b7a26e3330d029c694d545/3-Figure2-1.png)
Figure 2 from Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. | Semantic Scholar
![Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1 | Journal of Emerging Investigators Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1 | Journal of Emerging Investigators](https://emerginginvestigators.org/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBLZz09IiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--2992fd77695d72a2bb6c33bde278fd1bfddebb7f/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/jang.jpg)
Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1 | Journal of Emerging Investigators
![Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling | eLife Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling | eLife](https://iiif.elifesciences.org/lax/10734%2Felife-10734-fig2-v1.tif/full/1500,/0/default.jpg)
Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling | eLife
![Role of polo-like kinase 1 (PLK1) overexpression in cancer. In addition... | Download Scientific Diagram Role of polo-like kinase 1 (PLK1) overexpression in cancer. In addition... | Download Scientific Diagram](https://www.researchgate.net/publication/320073741/figure/fig1/AS:543603208069120@1506616512716/Role-of-polo-like-kinase-1-PLK1-overexpression-in-cancer-In-addition-to-its-role-in.png)
Role of polo-like kinase 1 (PLK1) overexpression in cancer. In addition... | Download Scientific Diagram
![Pharmaceuticals | Free Full-Text | Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth Pharmaceuticals | Free Full-Text | Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth](https://pub.mdpi-res.com/pharmaceuticals/pharmaceuticals-15-00523/article_deploy/html/images/pharmaceuticals-15-00523-ag.png?1650793455)
Pharmaceuticals | Free Full-Text | Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth
![Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis | PNAS Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis | PNAS](https://www.pnas.org/cms/10.1073/pnas.1101112108/asset/cb2e8612-b916-448b-b33f-842e0dd0f5bc/assets/graphic/pnas.1101112108fig01.jpeg)
Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis | PNAS
![Polo-like kinases: conservation and divergence in their functions and regulation | Nature Reviews Molecular Cell Biology Polo-like kinases: conservation and divergence in their functions and regulation | Nature Reviews Molecular Cell Biology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrm2653/MediaObjects/41580_2009_Article_BFnrm2653_Fig1_HTML.jpg)
Polo-like kinases: conservation and divergence in their functions and regulation | Nature Reviews Molecular Cell Biology
![Regulating a key mitotic regulator, polo‐like kinase 1 (PLK1) - Colicino - 2018 - Cytoskeleton - Wiley Online Library Regulating a key mitotic regulator, polo‐like kinase 1 (PLK1) - Colicino - 2018 - Cytoskeleton - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/dc4ea9ba-5a44-4b0f-89df-b0169a986589/cm21504-fig-0005-m.jpg)